You want to take this 80% of the time since Nidalee has a high killing potential especially after level 6. Ignite allows you to do absurd amount of damage with Nidalee's combo. Healing reduction is always nice too.
I've fiddled around with both ghost and exhaust but I prefer exhaust. In my opinion, exhaust is more useful than ghost is since you're probably already going to escape/catch with your passive and pounce. With exhaust, you can do a lot of things such as baiting escaping ganks, mitigating nukes, bursting enemies with lower MR and armour. However, I still prefer ignite since Nidalee snowballs extremely well. I might get this in situations like when it's a
vs matchup and our jungler is someone with weak presence.
Always get this in combination of whatever. It helps you set up for a combo or escaping sticky situations easily. Although both ignite and flash got nerfed, the utility that both summoner spells provides makes it worth it.
Very well-rounded rune setup for Midalee in both human and cat form. Provides Nidalee with necessary meatiness to balance the innate early squishiness while providing necessary damage for last hitting/harassing/trading/nuking.
I like to use the expensive hybrid marks. Numberwise, the hybrid runes are the most cost-efficient runes. It's extremely effective on Nidalee since she deals fair amount of both magic and physical damage. If you don't have hybrid runes or you don't like the feel of the runes like I initially did, feel free to use flat attack damage marks.
Why am I recommending armour when I'm a mid laner? Well my dear reader, the thing is you take PLENTY of physical damage early on. In fact, you probably take more physical than magical damage if you play Nidalee the way you're supposed to.
Pretty standard choice of runes for any mid laner. Magic resist helps you from getting your pathetic-base-MR-kitty-ass from getting bopped.
Quints are actually very open in terms of choices. You can run runes like MS, Flat AD/AP, or Hybrid Penetration. But once again, feel free to use any other runes like Flat HP or Magic Penetration. I just prefer going Flat AP/AD since it helps you harass/cs or sustain better in lane.